Naratriptan hydrochloride ( Naratriptan HCl | Amerge | Naramig | GR-85548A )

产品货号. M18015 CAS No. 143388-64-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Naratriptan hydrochloride
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

那拉曲坦盐酸盐是那拉曲坦的盐酸盐形式，那拉曲坦是一种磺酰胺，具有选择性血清素 (5-HT) 1 受体激动活性和抗偏头痛特性。
产品描述

Naratriptan Hydrochloride is the hydrochloride salt form of naratriptan, a sulfonamide with selective serotonin (5-HT) 1 receptor agonistic activity and anti-migraine property. Naratriptan hydrochloride binds selectively and with high affinity to the 5-HT1D and 5-HT1B receptor subtypes. Activation of these 5-HT1D/B receptors located on intracranial blood vessels leads to vasoconstriction and provides relief of migraine headaches. Naratriptan hydrochloride may also exerts its effect by stimulation of 5-HT1D/1B receptors on sensory nerve endings in the trigeminal system thereby decreasing the release of pro-inflammatory neuropeptides.
体外实验

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体内实验

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同义词

Naratriptan HCl | Amerge | Naramig | GR-85548A
通路

Others
靶点

Other Targets
受体

5-HT1
研究领域

Neurological Disease
适应症

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CAS Number

143388-64-1
分子量

371.93
分子式

C17H25N3O2S·HCl
纯度

>98% (HPLC)
溶解度

DMSO : ≥ 35 mg/mL; 94.10 mM
SMILES

CNS(=O)(=O)CCc1cc2c(cc1)[nH]cc2C1CCN(CC1)C.Cl
化学全称

N-Methyl-2-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]ethanesulfonamide hydrochloride

1.Sattar M, Hadgraft J, Lane ME.Int J Pharm. 2015 Sep 30;493(1-2):146-51.

计算器

产品手册

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